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Sadık Kükrer, MDObstetrics & Gynecology · Adana, Türkiye
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Fetal Growth Restriction: What Has Changed?

Last updated: 25 October 2026 · Editor: Sadık Kükrer, MD

  • The definition is based on an international Delphi consensus (Gordijn 2016).
  • ISUOG 2020: if UA-PI is >95th percentile or estimated fetal weight is <3rd percentile, delivery at 36+0–37+6 weeks; with cerebral redistribution, at 38+0–39+0 weeks.
  • ISUOG 2020: reversed end-diastolic flow at 32+0–33+6 weeks (may be considered after 30+0); absent end-diastolic flow at 34+0 weeks (may be considered after 32+0).
  • SMFM #52 uses different thresholds: absent end-diastolic velocity at 33–34 weeks, reversed at 30–32 weeks. Society recommendations are not mixed.
  • TRUFFLE: the difference in the primary outcome between groups was not significant (p for trend = 0.09).

References

  1. Gordijn SJ, et al. Ultrasound Obstet Gynecol. 2016;48(3):333-339. doi:10.1002/uog.15884. PMID: 26909664.
  2. Lees CC, et al. Ultrasound Obstet Gynecol. 2020;56(2):298-312. doi:10.1002/uog.22134. PMID: 32738107.
  3. Martins JG, et al. Am J Obstet Gynecol. 2020;223(4):B2-B17. doi:10.1016/j.ajog.2020.05.010. PMID: 32407785.
  4. Lees CC, et al. Lancet. 2015;385(9983):2162-2172. doi:10.1016/S0140-6736(14)62049-3. PMID: 25747582.