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Sadık Kükrer, MDObstetrics & Gynecology · Adana, Türkiye
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Preeclampsia: What Has Changed?

Last updated: 25 October 2026 · Editor: Sadık Kükrer, MD

  • ASPRE: aspirin in high-risk pregnancies reduced preterm preeclampsia: 1.6% vs 4.3%; OR 0.38 (95% CI 0.20–0.74).
  • CHAP: treating mild chronic hypertension reduced the composite primary outcome: 30.2% vs 37.0%; aRR 0.82 (95% CI 0.74–0.92). The difference in SGA was not significant: aRR 1.04 (95% CI 0.82–1.31).
  • PROGNOSIS: an sFlt-1/PlGF ratio ≤38 had a negative predictive value of 99.3% for ruling out preeclampsia within 1 week; a ratio >38 had a positive predictive value of 36.7% for preeclampsia within 4 weeks.
  • Magnesium sulfate (ACOG PB 222): 4–6 g IV loading dose over 20–30 minutes, then 1–2 g/h.

References

  1. Rolnik DL, et al. N Engl J Med. 2017;377(7):613-622. doi:10.1056/NEJMoa1704559. PMID: 28657417.
  2. Tita AT, et al. N Engl J Med. 2022;386(19):1781-1792. doi:10.1056/NEJMoa2201295. PMID: 35363951.
  3. Zeisler H, et al. N Engl J Med. 2016;374(1):13-22. doi:10.1056/NEJMoa1414838. PMID: 26735990.
  4. American College of Obstetricians and Gynecologists. Practice Bulletin No. 222. Obstet Gynecol. 2020;135(6):e237-e260. doi:10.1097/AOG.0000000000003891. PMID: 32443079.